Twelve murder cases remain unsolved in the city of Micropolis. All of the leads are dead ends and the homicide detectives are clueless of what to do next. Their last hope is you, the Mystery Master. Each of the 12 cases acts as a different game so that you only investigate one at a time. The objective is to be the first person to solve a case. Murder by the Dozen is set up so that each action is a turn.
Up to four players can play at the same time as each player will be allowed one action during their turn. After 20 minutes players will be allowed to attempt to solve a case. If the wrong person is accused then that player is removed from the case and their game is over. When playing, each player cannot learn from another player's turn. Clues are represented by a number so that a player can look up the clue in the manual. ~ Jonathan Sutyak, All Game Guide