Spider-Man is an action video game based upon the Marvel Comics character of the same name. It is loosely based on the 1990s Spider-Man and Spider-Man Unlimited cartoon series. The game was developed by Neversoft and published by Activision. Released originally for the PlayStation and Nintendo 64 in 2000, the game was subsequently ported to the Sega Dreamcast and PC. An alternate was also created for the Game Boy Color.
While attending a scientific demonstration hosted by the supposedly reformed Dr. Otto Octavius, Peter Parker (Spider-Man) witnesses the appearance of a Spider-Man impostor who steals Doctor Octavius's experiment. Eddie Brock mistakes this for the real Spider-Man and tries to take pictures, but his camera is shattered by the Spider-Man impostor. Angry, Brock worries that J. Jonah Jameson will fire him from his new job at the Daily Bugle; all of his rage causes the Venom symbiote to surface, and he swears revenge. Everyone present at the demonstration believes that Spider-Man took the experiment, causing the police to begin a manhunt for Spider-Man.
Spider-Man is told by Black Cat that the Jade Syndicate is robbing a bank and have taken hostages. After foiling the bank robbery, Spider-Man fights Scorpion in order to keep him from killing J. Jonah Jameson. After defeating Scorpion, Spider-Man is forced to flee from the police. Spider-Man encounters Daredevil, who questions Spider-Man but is eventually convinced of his innocence, then states that he will spread the word about Spider-Man's innocence. Immediately after Daredevil leaves, Spider-Man is ambushed by a police chopper and is chased across the city. Upon ditching the helicopter, Spider-Man reunites with Black Cat, who alerts him to two new problems: Rhino is attacking a power plant and Venom has kidnapped Mary Jane Watson in order to lure Spider-Man. Spider-Man defeats Rhino at the power plant, but Black Cat is injured and kidnapped by unknown parties posing as paramedics.
Human Torch encourages him, but Spider-Man cannot locate Venom until the villain appears and leads Spider-Man on an elaborate chase. The player ends up meeting The Lizard, who explains that Venom locked him down there and took control of the other lizard men. Lizard finally gives him directions to Venom's hideout. After battling Venom and rescuing Mary Jane, Spider-Man convinces Brock that someone has framed him, and they visit the Daily Bugle for information.